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Indophagolin

CAT: 0804-HY-134807-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134807-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM) . Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM) . Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].
CAS Number
1207660-00-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; Autophagy; P2X Receptor
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/indophagolin.html
Purity
98.05
Solubility
DMSO : 250 mg/mL (ultrasonic; warming)
Smiles
O=S(C1=CC2=C(C=C1Br)CCN2C(C3CC3)=O)(NC4=CC=C(Cl)C(C(F)(F)F)=C4)=O
Molecular Formula
C19H15BrClF3N2O3S
Molecular Weight
523.75
Precautions
H302, H315, H319, H335
References & Citations
[1]Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021; S2451-9456 (21) 00102-1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor; MUC2

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