DBCO-PEG4-Val-Cit-PAB-MMAF

DBCO-PEG4-Val-Cit-PAB-MMAF

• CAS Number: 2244602-23-9
• UNSPSC Description: DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-PEG4-Val-Cit-PAB-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dbco-peg4-val-cit-pab-mmaf.html
• Purity: 99.99
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: C[C@@H](C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@@H](NC(CCOCCOCCOCCOCCNC(CCC(N4C(C=CC=C5)=C5C#CC(C=CC=C6)=C6C4)=O)=O)=O)C(C)C)=O)=O)C=C3)=O)=O)=O)=O)OC
• Molecular Weight: 1672.01
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported