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Umbelliferone

CAT: 0804-HY-N0573-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0573-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats[1][2][3][4].
CAS Number
93-35-6
Product Name Alternative
7-Hydroxycoumarin; Hydrangin; NSC 19790
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Fluorescent Dye
Type
Natural Products
Related Pathways
Apoptosis; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Umbelliferone.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC=C(O)C=C2O1
Molecular Formula
C9H6O3
Molecular Weight
162.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Yu SM, et al. Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells. Mol Med Rep. 2015 Sep;12 (3) :3869-3873.|[2] Vasconcelos JF, et al. Effects of umbelliferone in a murine model of allergic airway inflammation. Eur J Pharmacol. 2009 May 1;609 (1-3) :126-31. |[3]Qin T, et al. Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt pathway. Behav Brain Res. 2017 Jan 15;317:147-156. |[4]Sim MO, et al. Anti-inflammatory and antioxidant effects of umbelliferone in chronic alcohol-fed rats. Nutr Res Pract. 2015 Aug;9 (4) :364-9. |[5]Luo DD, et al. Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress. Brain Res Bull. 2008 Sep 5;77 (1) :8-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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