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SARD279

CAT: 0804-HY-164807-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164807-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARD279 is a potent and selective Androgen Receptor degrader with DC50 value of 1099 nM. SARD279 can be used in prostate cancer research[1]. (Structure Note: Pink: target protein ligand ; Blue, : Hyt (HY-W001578) ; Black: linker (HY-W004896) )
CAS Number
1489236-55-6
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sard279.html
Purity
96.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCCOCCNC(CCCN(C1(C)C)C(N(C(C=C2)=CC(C(F)(F)F)=C2C#N)C1=O)=S)=O)CC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3
Molecular Formula
C33H41F3N4O5S
Molecular Weight
662.76
References & Citations
[1]Salami J, et al. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun Biol. 2018 Aug 2;1:100.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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