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C4b Protein

CAT: 1008-A428Size: 250 µLDry Ice: NoHazardous: No
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CAT#:1008-A428Size:250 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C4b is derived from native C4 upon cleavage and release of C4a. It is prepared by cleavage of purified C4 with the classical pathway activated protease C1s enzyme (#A104) . Native human C4b is a glycosylated (~7.3%) polypeptide containing three disulfide-linked chains. C4b is central to the function of two of the three pathways of complement. Both the classical and lectin pathways of complement activation generate surface-bound active proteases that cleave C4 (C1s in the classical pathway and MASP1/2 in the lectin pathway) . These enzymes cleave a peptide bond in C4 releasing the anaphylatoxin C4a and activating C4b. For a fraction of a second after proteolytic activation C4b can covalently attach to the surface of the target.
Description
Purified human C4b protein
Source
Normal human serum
Applications
See citations and technical data sheet for application info.
Concentration
1.0 mg/mL (refer to CoA for lot specific concentration)
Purity
>90% by SDS-PAGE
Activity
No activity
Form
Frozen liquid. 10 mM sodium phosphate, 145 mM NaCl, pH 7.3. No preservative, 0.22 μm filtered.
Molecular Weight
176,000 Da (2 chains)
Storage Conditions
Store at -70°C or below. Avoid freeze/thaw.

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