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C3c Protein

CAT: 1008-A417Size: 250 µLDry Ice: NoHazardous: No
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CAT#:1008-A417Size:250 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C3c is derived from iC3b (inactivated C3b) by proteolytic cleavage. iC3b is created by cleavage of C3b by factor I in the presence of factor H, CR1 or MCP. C3c can be produced by an additional cleavage by factor I if the iC3b is bound to CR1. Factor H cannot serve as a cofactor for this cleavage. C3c can also be produced by the action of trypsin-like proteases on iC3b. If the C3b precursor was attached to a surface, then the iC3b will remain attached to that surface and when iC3b is cleaved the C3c is released into the surrounding solution while the C3dg/C3d fragment remains on that surface. The breakdown of fluid phase C3b is similar, but in this case both C3c and C3dg/C3d are soluble fragments.
Description
Purified human C3c protein
Source
Normal human serum
Applications
See citations and technical data sheet for application info.
Concentration
1.0 mg/mL (refer to CoA for lot specific concentration)
Purity
>85% by SDS-PAGE
Activity
No activity
Form
Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 μm filtered.
Molecular Weight
139,000 Da (3 chains)
Storage Conditions
Store at -70°C or below. Avoid freeze/thaw.

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