Products for Research Use Only
RegisterLogin

Compound 401

CAT: 0957-S6506-25mgSize: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0957-S6506-25mgSize:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
168425-64-7
Target
DNA-PK
Applications
PI3K/Akt/mTOR
Smiles
C1COCCN1C2=CC (=O) N3C=CC4=CC=CC=C4C3=N2
Molecular Formula
C16H15N3O2
Additionnal Information
Compound 401 is a synthetic inhibitor of DNA-PK (IC50=0.28 μM) and mTOR (IC50=5.3 μM) . It has no inhibition on p110α/p85α PI3K (>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.
Storage Conditions
3 years -20°C powder

Chemical Information

2-Morpholin-4-ylpyrimido(2,1-A)isoquinolin-4-one
CAS Number168425-64-7
PubChem CID10039361
IUPAC Name2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-one
Molecular FormulaC16H15N3O2
Molecular Weight281.31
XLogP1.2
Topological Polar Surface Area45.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity532
SMILES
C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2
InChI
InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2
InChIKey
BVRDQVRQVGRNHG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Morpholin-4-ylpyrimido(2,1-A)isoquinolin-4-one
CAS: 168425-64-7
CID: 10039361
Formula: C16H15N3O2
MW: 281.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight281.31
XLogP31.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass281.116426730
Monoisotopic Mass281.116426730
Topological Polar Surface Area45.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity532
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
E7664-5mgTCS 401
S8003-01PQ 401
E7050-1mgCC-401
S8003-50mgPQ 401
E7664TCS 401
E7050CC-401
E6435-100mgCORM-401
E6435-25mgCORM-401
E6435-01CORM-401
E6435-1gCORM-401

Alternative Products

CatalogName
ALX-550-516-M025Compound A
XXC35825-01Compound 3a
Fr16729-01Compound Fr16729
PDK0296-01Compound PDK0296
PDK0264-01Compound PDK0264
Fr14090-01Compound Fr14090
Fr14018-01Compound Fr14018
Fr13991-01Compound Fr13991
Fr13830-01Compound Fr13830
Fr13814-01Compound Fr13814

Popular Products