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Nusinersen

CAT: 0957-E6580-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:0957-E6580-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1258984-36-9
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Additionnal Information
Nusinersen is an 18-mer, 2′-O- (2-methoxyethyl) phosphorothioate antisense oligonucleotide used for treating spinal muscular atrophy (SMA) . It binds specifically to the intronic splice silencer N1 (ISS-N1) site in intron 7 of SMN2 pre-mRNA, blocking the binding of splicing repressors hnRNP A1/A2. This promotes inclusion of exon 7 during splicing, restoring full-length SMN protein production in SMA patients.

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