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Antalarmin hydrochloride

CAT: 0957-E6536-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:0957-E6536-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
220953-69-5
Target
CRFR
Applications
GPCR & G Protein
Smiles
CC1=C (N2C (C) =C (C) C3=C (N (CCCC) CC) N=C (C) N=C32) C (C) =CC (C) =C1.[H]Cl
Molecular Formula
C24H35ClN4
Additionnal Information
Antalarmin hydrochloride is an orally active, non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist exhibiting a Ki value of 1 nM. This compound inhibits CRH-induced ACTH secretion and attenuates CRH-mediated and novelty-induced anxiety-like behaviors in preclinical models. Additionally, antalarmin hydrochloride demonstrates anti-inflammatory activity in arthritis models and reduces stress-induced gastric ulceration associated with irritable bowel syndrome.

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