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Proxalutamide (GT0918)

CAT: 0957-S9898-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S9898-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1398046-21-3
Target
Androgen Receptor
Applications
Endocrinology & Hormones
Smiles
CC1 (C) N (C (=S) N (C1=O) C2=C (F) C (=C (C=C2) C#N) C (F) (F) F) C3=CN=C (CCCC4=NC=CO4) C=C3
Molecular Formula
C24H19F4N5O2S
Additionnal Information
Proxalutamide (GT0918) is a second-generation androgen receptor antagonist that binds to the ligand-binding domain of AR with an IC50 of 32 nM in the AR competive binding assays.
Storage Conditions
3 years -20°C powder

Chemical Information

Pruxelutamide

Proxalutamide is under investigation in clinical trial NCT03899467 (The Safety and Tolerability of Proxalutamide (GT0918) in Subjects With Metastatic Castrate Resistant Prostate Cancer).

CAS Number1398046-21-3
PubChem CID60194102
IUPAC Name4-[4,4-dimethyl-3-[6-[3-(1,3-oxazol-2-yl)propyl]-3-pyridinyl]-5-oxo-2-sulfanylideneimidazolidin-1-yl]-3-fluoro-2-(trifluoromethyl)benzonitrile
Molecular FormulaC24H19F4N5O2S
Molecular Weight517.5
XLogP4.3
Topological Polar Surface Area118
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity893
SMILES
CC1(C(=O)N(C(=S)N1C2=CN=C(C=C2)CCCC3=NC=CO3)C4=C(C(=C(C=C4)C#N)C(F)(F)F)F)C
InChI
InChI=1S/C24H19F4N5O2S/c1-23(2)21(34)32(17-9-6-14(12-29)19(20(17)25)24(26,27)28)22(36)33(23)16-8-7-15(31-13-16)4-3-5-18-30-10-11-35-18/h6-11,13H,3-5H2,1-2H3
InChIKey
KCBJGVDOSBKVKP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pruxelutamide
CAS: 1398046-21-3
CID: 60194102
Formula: C24H19F4N5O2S
MW: 517.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight517.5
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass517.11955869
Monoisotopic Mass517.11955869
Topological Polar Surface Area118 Ų
Heavy Atom Count36
Formal Charge0
Complexity893
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
S9898-25mgProxalutamide (GT0918)
MBS3601663-01Proxalutamide
A19586-10Proxalutamide 10mg
A19586-5Proxalutamide 5mg
A19586-1Proxalutamide 1mg

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