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AZD5153 6-hydroxy-2-naphthoic acid

CAT: 0957-S8344-10mM/1mLSize: 10 mM/1mLDry Ice: YesHazardous: No
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CAT#:0957-S8344-10mM/1mLSize:10 mM/1mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1869912-40-2
Synonyms
AZD5153 HNT salt
Target
Epigenetic Reader Domain
Applications
Epigenetics
Smiles
CC1C (=O) N (CCN1CCOC2=CC=C (C=C2) C3CCN (CC3) C4=NN5C (=NN=C5OC) C=C4) C.C1=CC2=C (C=CC (=C2) O) C=C1C (=O) O
Molecular Formula
C25H33N7O3.C11H8O3
Additionnal Information
AZD5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.
Storage Conditions
2 years -80 in solvent

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Alternative Products

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MBS3846276-01AZD5153 6-Hydroxy-2-naphthoic acid
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A21852-10AZD5153 6-Hydroxy-2-naphthoic acid 10mg
A21852-1AZD5153 6-Hydroxy-2-naphthoic acid 1mg
A21852-100AZD5153 6-Hydroxy-2-naphthoic acid 100mg
A21852-50AZD5153 6-Hydroxy-2-naphthoic acid 50mg
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