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Zoligratinib (Debio-1347)

CAT: 0957-S7665-5mgSize: 5 mgDry Ice: YesHazardous: No
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CAT#:0957-S7665-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1265229-25-1
Synonyms
CH5183284, FF284
Target
FGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1=NC2=C (N1) C=C (C=C2) N3C (=C (C=N3) C (=O) C4=CC5=CC=CC=C5N4) N
Molecular Formula
C20H16N6O
Additionnal Information
Zoligratinib (Debio-1347, CH5183284, FF284) is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1.
Storage Conditions
2 years -80 in solvent

Chemical Information

Zoligratinib

Ch5183284 has been used in trials studying the treatment of Solid Tumours.

CAS Number1265229-25-1
PubChem CID66555680
IUPAC Name[5-amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone
Molecular FormulaC20H16N6O
Molecular Weight356.4
XLogP3.9
Topological Polar Surface Area105
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity573
SMILES
CC1=NC2=C(N1)C=C(C=C2)N3C(=C(C=N3)C(=O)C4=CC5=CC=CC=C5N4)N
InChI
InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)
InChIKey
BEMNJULZEQTDJY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Zoligratinib
CAS: 1265229-25-1
CID: 66555680
Formula: C20H16N6O
MW: 356.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight356.4
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass356.13855916
Monoisotopic Mass356.13855916
Topological Polar Surface Area105 Ų
Heavy Atom Count27
Formal Charge0
Complexity573
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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