KN-62

CAT: 0957-S7422-5mgSize: 5 mgDry Ice: YesHazardous: No

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CAT#:0957-S7422-5mgSize:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

127191-97-3

Target

CaMK

Applications

Neuronal Signaling

Smiles

CN (C (CC1=CC=C (C=C1) OS (=O) (=O) C2=CC=CC3=C2C=CN=C3) C (=O) N4CCN (CC4) C5=CC=CC=C5) S (=O) (=O) C6=CC=CC7=C6C=CN=C7

Molecular Formula

C38H35N5O6S2

Additionnal Information

KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM) . It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.

Storage Conditions

2 years -80 in solvent

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E5833-1g	KN-93 hydrochloride
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S7423-1g	KN-93 Phosphate
S7423-200mg	KN-93 Phosphate
S6507-2mg	KN-92 phosphate
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Alternative Products

Catalog	Name
A8180-5	KN-62
FB24811-01	KN 62

KN-62

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