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Tyrphostin AG-528

CAT: 0957-S6805-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S6805-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
133550-49-9
Synonyms
Tyrphostin B66, AG 528
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
C1CN (C2=CC=CC=C21) C (=O) C (=CC3=CC (=C (C=C3) O) O) C#N
Molecular Formula
C18H14N2O3
Additionnal Information
Tyrphostin AG-528 (Tyrphostin B66) is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4.9 μM and 2.1 μM, respectively. Tyrphostin AG-528 exhibits anticancer activity.
Storage Conditions
3 years -20°C powder

Chemical Information

Tyrphostin AG528
CAS Number133550-49-9
PubChem CID1838043
IUPAC Name(E)-2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
Molecular FormulaC18H14N2O3
Molecular Weight306.3
XLogP2.6
Topological Polar Surface Area84.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity536
SMILES
C1CN(C2=CC=CC=C21)C(=O)/C(=C/C3=CC(=C(C=C3)O)O)/C#N
InChI
InChI=1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+
InChIKey
MYKCTDWWIWGLHW-NTEUORMPSA-N
Chemical Structure
2D Structure
2D structure of Tyrphostin AG528
CAS: 133550-49-9
CID: 1838043
Formula: C18H14N2O3
MW: 306.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.3
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass306.10044231
Monoisotopic Mass306.10044231
Topological Polar Surface Area84.6 Ų
Heavy Atom Count23
Formal Charge0
Complexity536
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-100499-01Tyrphostin AG 528
C12226-5mgTyrphostin AG-528
A17072-200Tyrphostin AG-528 200mg
A17072-5Tyrphostin AG-528 5mg
A17072-100Tyrphostin AG-528 100mg
A17072-25Tyrphostin AG-528 25mg
A17072-10Tyrphostin AG-528 10mg
A17072-50Tyrphostin AG-528 50mg
A17072-10mM-DTyrphostin AG-528 10mM * 1mL in DMSO
A2477-5.1Tyrphostin AG 1296

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