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Prucalopride Succinate

CAT: 0957-S4247-50mgSize: 50 mgDry Ice: YesHazardous: No
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CAT#:0957-S4247-50mgSize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
179474-85-2
Synonyms
R-108512
Target
5-HT Receptor
Applications
Neuronal Signaling
Smiles
COCCCN1CCC (CC1) NC (=O) C2=CC (=C (C3=C2OCC3) N) Cl.C (CC (=O) O) C (=O) O
Molecular Formula
C18H26ClN3O3.C4H6O4
Additionnal Information
Prucalopride (R-108512) is a selective, high affinity 5-HT4 receptor agonist. The Ki values of prucalopride for human 5-HT (4a) and 5-HT (4b) receptor are 2.5 nM and 8 nM, respectively.
Storage Conditions
2 years -80 in solvent

Chemical Information

Prucalopride Succinate

Prucalopride Succinate is the succinate salt form of prucalopride, an orally bioavailable dihydro-benzofuran-carboxamide and selective serotonin (5-HT4) receptor agonist, with gastrointestinal (GI) prokinetic activity. Upon oral administration, prucalopride specifically targets, binds to and stimulates the 5-HT4 receptor. This alters colonic motility patterns and stimulates colonic mass movements. This may normalize bowel movements and may relief chronic constipation. In addition, by increasing esophageal and gastric motility, prucalopride may also provide relief for aspiration-associated symptoms.

CAS Number179474-85-2
PubChem CID9870009
IUPAC Name4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acid
Molecular FormulaC22H32ClN3O7
Molecular Weight486.0
Topological Polar Surface Area151
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Heavy Atom Count33
Formal Charge0
Complexity538
SMILES
COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
InChI
InChI=1S/C18H26ClN3O3.C4H6O4/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;5-3(6)1-2-4(7)8/h11-12H,2-10,20H2,1H3,(H,21,23);1-2H2,(H,5,6)(H,7,8)
InChIKey
QZRSNVSQLGRAID-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Prucalopride Succinate
CAS: 179474-85-2
CID: 9870009
Formula: C22H32ClN3O7
MW: 486.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight486.0
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass485.1928781
Monoisotopic Mass485.1928781
Topological Polar Surface Area151 Ų
Heavy Atom Count33
Formal Charge0
Complexity538
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS3602709-01Prucalopride succinate
HY-12694-01Prucalopride (succinate)
RM-P181201-01Prucalopride Succinate Impurity A
HY-12694R-01Prucalopride (succinate) (Standard)
463152Prucalopride Succinate-13CD3
RM-P181213-01Prucalopride Succinate Impurity M
RM-P181208-01Prucalopride Succinate Impurity H
RM-P181211-01Prucalopride Succinate Impurity K
RM-P181206-01Prucalopride Succinate Impurity F
RM-P181214-01Prucalopride Succinate Impurity N

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