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SEC inhibitor KL-1

CAT: 0957-S2973-25mgSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-S2973-25mgSize:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
900308-84-1
Synonyms
KL-1
Target
Others
Applications
Others
Smiles
COC1=CC=CC (=C1) C (=O) CC (=O) C (=O) NC2=C (C) C=CC (=C2) Cl
Molecular Formula
C18H16ClNO4
Additionnal Information
SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM.
Storage Conditions
3 years -20°C powder

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