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Dacomitinib

CAT: 0957-S2727-50mgSize: 50 mgDry Ice: YesHazardous: No
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CAT#:0957-S2727-50mgSize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1110813-31-4
Synonyms
PF299804, PF299
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
COC1=C (C=C2C (=C1) N=CN=C2NC3=CC (=C (C=C3) F) Cl) NC (=O) C=CCN4CCCCC4
Molecular Formula
C24H25ClFN5O2
Additionnal Information
Dacomitinib is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.
Storage Conditions
2 years -80 in solvent

Alternative Products

CatalogName
C17028-10mgDacomitinib
C03446-25mgDacomitinib hydrate
HY-13272R-01Dacomitinib (Standard)
HY-13272S3-01Dacomitinib-d10

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