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RAF265 (CHIR-265)

CAT: 0957-S2161-10mM/1mLSize: 10 mM/1mLDry Ice: YesHazardous: No
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CAT#:0957-S2161-10mM/1mLSize:10 mM/1mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
927880-90-8
Target
Raf
Applications
MAPK
Smiles
CN1C2=C (C=C (C=C2) OC3=CC (=NC=C3) C4=NC=C (N4) C (F) (F) F) N=C1NC5=CC=C (C=C5) C (F) (F) F
Molecular Formula
C24H16F6N6O
Additionnal Information
RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.
Storage Conditions
2 years -80 in solvent

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