Veliparib (ABT-888)

CAT: 0957-S1004-50mgSize: 50 mgDry Ice: YesHazardous: No

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CAT#:0957-S1004-50mgSize:50 mg

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CAS Number

912444-00-9

Synonyms

NSC 737664

Target

PARP

Applications

DNA Damage/DNA Repair

Smiles

CC1 (CCCN1) C2=NC3=C (C=CC=C3N2) C (=O) N

Molecular Formula

C13H16N4O

Additionnal Information

Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.

Storage Conditions

2 years -80 in solvent

Chemical Information

Veliparib

Veliparib is a benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor.

CAS Number	912444-00-9
PubChem CID	11960529
IUPAC Name	2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
Molecular Formula	C13H16N4O
Molecular Weight	244.29
XLogP	0.5
Topological Polar Surface Area	83.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	18
Formal Charge	0
Complexity	348

SMILES

C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N

InChI

InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1

InChIKey

JNAHVYVRKWKWKQ-CYBMUJFWSA-N

Chemical Structure

2D Structure

CAS: 912444-00-9

CID: 11960529

Formula: C13H16N4O

MW: 244.29

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	244.29
XLogP3	0.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	244.13241115
Monoisotopic Mass	244.13241115
Topological Polar Surface Area	83.8 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	348
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
E7366	Veliparib dihydrochloride
E7366-5mg	Veliparib dihydrochloride
S1002-1g	ABT-737
E7858-5mg	ABT-639
S1002-10mM/1mL	ABT-737
E7858	ABT-639
E8015	ABT-239
E8015-5mg	ABT-239
S1002-50mg	ABT-737
S1002-5mg	ABT-737

Alternative Products

Catalog	Name
A3002-5.1	ABT-888 (Veliparib)
SC0020-5mg	Veliparib (ABT-888)
MBS132020-01	ABT-888 Veliparib
abx282654-01	Veliparib 2HCl (ABT-888)
A10026-500	ABT-888 (Veliparib) 500mg
A10026-200	ABT-888 (Veliparib) 200mg
A10026-10	ABT-888 (Veliparib) 10mg
A10026-5	ABT-888 (Veliparib) 5mg
A10026-100	ABT-888 (Veliparib) 100mg
A10026-50	ABT-888 (Veliparib) 50mg

Veliparib (ABT-888)

Chemical Information

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