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MS4078

CAT: 0957-S0072-1gSize: 1 gDry Ice: NoHazardous: No
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CAT#:0957-S0072-1gSize:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2229036-62-6
Target
ALK
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC (=C (C=C1C2CCN (CC2) CC (=O) NCCNC3=CC=CC4=C3C (=O) N (C4=O) C5CCC (=O) NC5=O) OC (C) C) NC6=NC=C (C (=N6) NC7=CC=CC=C7S (=O) (=O) C (C) C) Cl
Molecular Formula
C45H52ClN9O8S
Additionnal Information
MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.
Storage Conditions
3 years -20°C powder

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