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DM4

CAT: 0957-E7058-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E7058-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
796073-69-3
Target
Microtubule Associated
Applications
Cytoskeletal Signaling
Molecular Formula
C38H54ClN3O10S
Additionnal Information
DM4 is a potent maytansinoid and potent inhibitor of tubulin. It binds to α/β-tubulin heterodimers and inhibits tubulin polymerization and microtubule assembly, leading to enhanced microtubule destabilization. This strong antimitotic activity results in suppressed microtubule dynamics, causing mitotic arrest and apoptotic cell death, making it valuable for studying acute myeloid leukemia (AML) therapies.

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