Palbociclib 2HCL

CAT: 0957-E6025-25mgSize: 25 mgDry Ice: NoHazardous: No
CAT#:0957-E6025-25mgSize:25 mg
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CAS Number
571189-11-2
Synonyms
PD-0332991 dihydrochloride
Target
CDK
Applications
Cell Cycle
Molecular Formula
C24H31Cl2N7O2
Additionnal Information
Palbociclib 2HCL (PD-0332991 dihydrochloride), the dihydrochloride salt of Palbociclib, is a highly specific inhibitor of Cdk4 and Cdk6, with IC50 values of 11 nM and 16 nM, respectively. It is a potent antiproliferative agent against retinoblastoma (Rb) -positive tumor cells in vitro, inducing a selective G1 cell cycle arrest and reducing phosphorylation at Ser780 and Ser795 on the Rb protein.

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