Vardenafil

CAT: 0957-E4803-100mgSize: 100 mgDry Ice: NoHazardous: No

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CAT#:0957-E4803-100mgSize:100 mg

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CAS Number

224785-90-4

Target

PDE

Applications

Metabolism

Molecular Formula

C23H32N6O4S

Additionnal Information

Vardenafil is an orally active and selective inhibitor of phosphodiesterase-5 (PDE5), with an IC50 value of 0.7 nM, respectively. Vardenafil acts as a competitive inhibitor of cyclic guanosine monophosphate (cGMP) hydrolysis, thereby increasing cGMP levels. Vardenafil can be used for the research of erectile dysfunction, hepatitis, diabetes.

Chemical Information

Vardenafil

Vardenafil is the sulfonamide resulting from formal condensation of the sulfo group of 4-ethoxy-3-(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one-2-yl)benzenesulfonic acid and the secondary amino group of 4-ethylpiperazine. It has a role as a vasodilator agent and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor. It is a N-alkylpiperazine, an imidazotriazine and a N-sulfonylpiperazine.

CAS Number	224785-90-4
PubChem CID	135400189
IUPAC Name	2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Molecular Formula	C23H32N6O4S
Molecular Weight	488.6
XLogP	2.5
Topological Polar Surface Area	118
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Heavy Atom Count	34
Formal Charge	0
Complexity	854

SMILES

CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C

InChI

InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)

InChIKey

SECKRCOLJRRGGV-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 224785-90-4

CID: 135400189

Formula: C23H32N6O4S

MW: 488.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	488.6
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	488.22057470
Monoisotopic Mass	488.22057470
Topological Polar Surface Area	118 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	854
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
HY-B0442-01	Vardenafil
HY-B0442S1	Vardenafil-d4
FP159167-01	Pseudo Vardenafil
CS-P-00296	Vardenafil Dimer
RM-V041433-01	Vardenafil-D7
RG-A261143-01	Vardenafil-D5
RM-V041413-01	Hydroxy Vardenafil
A10965-100	Vardenafil 100mg
MBS5811788	Vardenafil oxopiperazine

Vardenafil

Chemical Information

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