Products for Research Use Only
RegisterLogin

BGB-3245 (Brimarafenib)

CAT: 0957-E4599-100mgSize: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0957-E4599-100mgSize:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1643326-82-2
Synonyms
Brimarafenib, Brimarafenibum
Target
Raf
Applications
MAPK
Molecular Formula
C24H17F3N4O4
Additionnal Information
BGB-3245 (Brimarafenib, Brimarafenibum) is an inhibitor of Raf kinase. BGB-3245 displays potent effects against different RAF isoforms, including BRAF Class I/II/III mutations, BRAF fusions, and heterodimerization with CRAF in preclinical models. It also exhibits antineoplastic effects.

Chemical Information

Brimarafenib

Brimarafenib is a small molecule drug. The usage of the INN stem '-rafenib' in the name indicates that Brimarafenib is a Raf (rapidly accelerated fibrosarcoma) kinase inhibitor. Brimarafenib is under investigation in clinical trial NCT04249843 (Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants with Advanced or Refractory Tumors). Brimarafenib has a monoisotopic molecular weight of 482.12 Da.

CAS Number1643326-82-2
PubChem CID117807031
IUPAC Name1-[(1S,1aS,6bS)-5-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-yl]-3-(2,4,5-trifluorophenyl)urea
Molecular FormulaC24H17F3N4O4
Molecular Weight482.4
XLogP2.6
Topological Polar Surface Area102
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity839
SMILES
C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)O[C@H]5[C@@H]4[C@@H]5NC(=O)NC6=CC(=C(C=C6F)F)F
InChI
InChI=1S/C24H17F3N4O4/c25-13-8-15(27)16(9-14(13)26)29-24(33)31-21-20-12-7-10(1-3-17(12)35-22(20)21)34-18-5-6-28-23-11(18)2-4-19(32)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,30,32)(H2,29,31,33)/t20-,21-,22-/m0/s1
InChIKey
USMWOBMHNWNPAP-FKBYEOEOSA-N
Chemical Structure
2D Structure
2D structure of Brimarafenib
CAS: 1643326-82-2
CID: 117807031
Formula: C24H17F3N4O4
MW: 482.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight482.4
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass482.12018952
Monoisotopic Mass482.12018952
Topological Polar Surface Area102 Ų
Heavy Atom Count35
Formal Charge0
Complexity839
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
E1848-1gBGB-8035
E1297-01BGB 15025
E1297-25mgBGB 15025
E1297-5mgBGB 15025
E1848-100mgBGB-8035
E1848-25mgBGB-8035
E1848-01BGB-8035
E1848-5mgBGB-8035
E1297-100mgBGB 15025
E1993-5mgCatadegbrutinib (BGB-16673)

Alternative Products

CatalogName
C03219-5mgBGB-3245 (Brimarafenib)
HY-159508-01Brimarafenib
BA6386-5BGB-102
HY-P991613BGB-A445
JH914116BGB-15025
MBS5764893BGB-290
GTR19217396-01BGB-283
M36520-01BGB-8035
C01600-100mgBGB 15025
GTR17967655Bgb Antibody

Popular Products