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DBr-1

CAT: 0957-E1994-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:0957-E1994-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Epigenetic Reader Domain
Applications
Epigenetics
Additionnal Information
DBr-1 is a DCAF1-BRD9 PROTAC, created by linking the BRD9 binder BI-956448 to the DCAF1 scaffold via a piperidine-aliphatic carbon linker. It is a potent and selective degrader of BRD9 with a DC50 of 90 nM. It overcomes intrinsic resistance to VHL-degraders, positioning DCAF1-PROTACs as a promising strategy to counter ligase-mediated resistance.

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