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NVL-655

CAT: 0957-E1961-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E1961-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2739866-40-9
Synonyms
ALK-IN-27
Target
ALK
Applications
Protein Tyrosine Kinase
Molecular Formula
C23H22ClFN6O
Additionnal Information
NVL-655 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with potential antineoplastic activity in the Ba/F3 xenograft model. It also exhibits significant inhibitory activity against ROS1, LTK, PYK2, TRKB, and FAK, with an IC50 ≤10-fold ALK and demonstrates high potency against specific ALK mutations, with an IC50 of <0.73 nM, 7 nM, 3 nM, 3 nM for G1202R, G1202R/L1196M, G1202R/G1269A and G1202R/L1198F respectively.

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