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LUNA18

CAT: 0957-E1576-1mgSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-E1576-1mgSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2676177-63-0
Synonyms
Paluratide
Target
Ras
Applications
Apoptosis
Molecular Formula
C73H105F5N12O12
Additionnal Information
LUNA18 (Paluratide) is an orally bioavailable 11-mer cyclic peptide KRAS inhibitor for the intracellular tough target RAS. It binds to KRASG12D with a kd of 0.043 nM and blocks KRASG12D–SOS1 interaction at IC50 of < 2.2 nM. It also exhibits antiproliferative activity in KRAS-mutant cancer cell lines with an IC50 of 1.4 nM in AsPC-1 pancreatic cancer cells.

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