LY 345899

CAT: 0957-E1317-5mgSize: 5 mgDry Ice: NoHazardous: No
CAT#:0957-E1317-5mgSize:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
10538-99-5
Target
Others
Applications
Others
Molecular Formula
C20H21N7O7
Additionnal Information
LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1; DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM, respectively. It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models.

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