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Hemitoxin

CAT: 0804-HY-P5788Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P5788Size:1 Each
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Description
Hemitoxin, a scorpion-venom peptide, is a K+ channel blocker. Hemitoxin blocks rat Kv1.1, Kv1.2 and Kv1.3 channels expressed in Xenopus oocytes with IC50 values of 13 nM, 16 nM and 2 nM, respectively[1].
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hemitoxin.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@H]1CCCCN)=O)NC2=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC3=CC=C(C=C3)O)C(NC4)=O)=O)NC1=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CO)C(N6[C@@H](CCC6)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]2CC(N)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(O)=O)=O)NC4=O)C(N8[C@@H](CCC8)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@H]7CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N
Molecular Formula
C159H259N49O49S8
Molecular Weight
3897.58
References & Citations
[1]Najet Srairi-Abid, et al. Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus. FEBS J. 2008 Sep;275 (18) :4641-50.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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