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WK298

CAT: 0804-HY-107466Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107466Size:1 Each
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Description
WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure[1].
CAS Number
1067654-70-9
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wk298.html
Smiles
O=C(N1C[C@H](CC1)N(C)CCCN(C)C)C2=C(C3=C(C4=CC=CC=C4)N=CN3CC5=CC=C(C=C5)Cl)C6=CC=C(Cl)C=C6N2
Molecular Formula
C35H38Cl2N6O
Molecular Weight
629.62
References & Citations
[1]Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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