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Piclamilast (Standard)

CAT: 0804-HY-12887RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12887RSize:1 Each
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Description
Piclamilast (Standard) is the analytical standard of Piclamilast. This product is intended for research and analytical applications. Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC50 values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively[1][2][3][4].
CAS Number
144035-83-6
Product Name Alternative
RP 73401 (Standard) ; RPR 73401 (Standard)
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/piclamilast-standard.html
Smiles
O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC)C(OC3CCCC3)=C2
Molecular Formula
C18H18Cl2N2O3
Molecular Weight
381.25
References & Citations
[1]M J Ashton, et al. Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3- (cyclopentyloxy) -4-methoxybenzamides and analogues. J Med Chem. 1994 May 27;37 (11) :1696-703.|[2]Manuel Mata, et al. Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H (2) O (2) via mechanisms involving AP-1 activation. Free Radic Res. 2012 May;46 (5) :690-9.|[3]Edoardo Parrella, et al. Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways. J Biol Chem . 2004 Oct 1;279 (40) :42026-40.|[4]T Ukita, et al. Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives. J Med Chem. 1999 Mar 25;42 (6) :1088-99.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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