Ceratotoxin-2

• Description:

  Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel blocker with IC50s of 8 nM and 88 nM against Nav1.2/β1 and Nav1.3/β1, respectively[1].

• Product Name Alternative:

  CcoTx2; β-TRTX-cm1b

• UNSPSC:

  12352209

• Target:

  Sodium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ceratotoxin-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CC4=CC=C(O)C=C4)=O)CC5=CC=C(O)C=C5)=O)CCCCN)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCCCN)=O)CCC1)=O)CC(O)=O)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC7=CNC8=CC=CC=C78)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO)=O)=O)CO)=O)CCCCN)=O)CC9=CC=CC=C9)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6[C@@H](C)O)=O)CC%12=CC=C(O)C=C%12)=O)CC(N)=O)=O)CCCCN)=O

• Molecular Formula:

  C177H260N52O49S6

• Molecular Weight:

  4092.67

• References & Citations:

  [1]Bosmans F, et al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol. 2006 Feb;69 (2) :419-29.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [880885-98-3]