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Procathepsin K (human), (recombinant)

CAT: 1106-ALX-201-239-C010Size: 10 µgDry Ice: YesHazardous: No
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CAT#:1106-ALX-201-239-C010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Specifications
≥1’000mU/mg protein. One unit is defined as the amount of enzyme that hydrolyzes 1μmol of substrate per min. at 37°C, pH 5.5.
Product Name Alternative
Procathepsin O, Procathepsin O2, Procathepsin X
Certification
RUO
UniProt
P43235
Source
Produced in E. coli (aa 19-329) . Methionine was introduced at aa 18 to create a new N-terminal sequence (MEEIL) .
Stability
Stable for several months when stored at -80°C. After activation, cathepsin is highly autoproteolytic. When not used immediately, add MMTS (Methyl methanethiosulfonate) to 1mM final concentration for stabilization and shock freeze in liquid nitrogen. Do not store dilutions of the enzyme.
Concentration
150μg/ml
Purity
≥95% (SDS-PAGE)
Molecular Weight
~35kDa
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Notes
Inhibitors: Cathepsin K is inhibited by leupeptin (Prod. No. ALX-260-009) (IC 50 =70nM), E-64 (IC 50 =5nM) or cystatine. Minimal effects exhibit pepstatin, phenylmethylsulfonyl fluoride (Prod. No. ALX-270-184), inhibitors of aspartyl and serine proteases. No inhibition was observed by addition of EDTA or phenanthroline, classical inhibitors of metalloproteases.
Formulation
Liquid. In 25mM TRIS, pH 8.0, containing 500mM sodium chloride.

UniProtKB · P43235

Cathepsin K

CATK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43235
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTSK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.22.38
Processing
Precursor
Secondary accessions
Q6FHS6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneLysosomeMembraneSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseThiol protease

Domain

Signal

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