Products for Research Use Only

Cyclophilin A (human), (recombinant)

CAT: 1106-BML-SE105-0100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:1106-BML-SE105-0100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
Peptidylproline cis-trans-isomerase
Certification
RUO
UniProt
P62937
Source
Produced in E. coli .
Purification
Purified by multi-step chromatography.
Stability
Caution: Loss of protein may occur at high dilutions due to adsorption to container surfaces. Freezing of the enzyme or storage of the enzyme in diluted form could lead to loss of activity. In order to best maintain the endotoxin specification and peptidyl prolyl isomerase activity, it is recommended that aliquots be withdrawn with sterile pipet tips, if possible under a sterile hood.
Endotoxin
Packaged under sterile conditions with a maximum endotoxin content of 0.1 EU/μg determined using the chromogenic Limulus amebocyte lysate (LAL) test.
Purity
≥95% (SDS-PAGE)
Molecular Weight
18kDa
Shipping Conditions
Blue Ice
Storage Conditions
+4°C
Formulation
Liquid. In 20 mM TRIS-HCl, pH 7.8.
Applications Notes
Catalyzes the cis-trans -isomerization of X-Pro-peptide bonds. Protein folding reactions that are limited by the isomerization of X-Pro-peptide bonds are accelerated by cyclophilin A. Cyclophilin A binds tightly to the immunosuppressive agent Cyclosporin A. This complex binds calcineurin (PP2B) and inhibits its phosphatase activity.