EB1

• UNSPSC Description:

  EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation[1][2].

• Target Antigen:

  Apoptosis; Eukaryotic Initiation Factor (eIF); MNK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/eb1.html

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  NC1=NNC2=C1C(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2

• Molecular Weight:

  286.33

• References & Citations:

  [1]Bou-Petit E, et al. Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor. J Med Chem. 2022 Apr 28;65(8):6070-6087. |[2]Aboukhatwa SM, et al. Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition. Bioorg Chem. 2022 Dec;129:106126.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  42951-68-8