Products for Research Use Only
RegisterLogin

AZ 960

CAT: 1568-C16703-01Size: 10 mM / 1 mLDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:1568-C16703-01Size:10 mM / 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
905586-69-8
SKU
C16703-10mg
Target
JAK
Applications
Angiogenesis
Smiles
CC1=CC (=NN1) NC2=C (C=C (C (=N2) NC (C) C3=CC=C (C=C3) F) C#N) F
Molecular Formula
C18H16F2N6
Additionnal Information
AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. AZ 960 induces apoptosis and growth arrest.
Storage Conditions
2 years -80 in solvent

Chemical Information

AZ-960
CAS Number905586-69-8
PubChem CID25099184
IUPAC Name5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile
Molecular FormulaC18H16F2N6
Molecular Weight354.4
XLogP4.4
Topological Polar Surface Area89.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity503
SMILES
CC1=CC(=NN1)NC2=C(C=C(C(=N2)N[C@@H](C)C3=CC=C(C=C3)F)C#N)F
InChI
InChI=1S/C18H16F2N6/c1-10-7-16(26-25-10)23-18-15(20)8-13(9-21)17(24-18)22-11(2)12-3-5-14(19)6-4-12/h3-8,11H,1-2H3,(H3,22,23,24,25,26)/t11-/m0/s1
InChIKey
SUNXHXDJOIXABJ-NSHDSACASA-N
Chemical Structure
2D Structure
2D structure of AZ-960
CAS: 905586-69-8
CID: 25099184
Formula: C18H16F2N6
MW: 354.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.4
XLogP34.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass354.14045086
Monoisotopic Mass354.14045086
Topological Polar Surface Area89.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity503
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
C08811-50mgAZ 3146
C08811-1gAZ 3146
C08823-5mgAZ 628
C08811-01AZ 3146
C08823-01AZ 628
C07006-10mM/1mLAZ-33
C08823-1gAZ 628
C17039-10mM/1mLAZ 628
C17039AZ 628
C07006-01AZ-33

Alternative Products

CatalogName
303-150Riboclear (RNA Cleanup)
TBS10485-100Tribio InVivoMAb Anti-Mouse TIGIT & PD-L1 Bispecific Antibody
TBS10191-1mgTetrahydrocannabinol (THC) Monoclonal Antibody
TBI3024-25MGAc-Leu-Leu-Nle-CHO (ALLN), Calpain inhibitor
122-101ExgeneTM Forensic SV mini
TBS10483-100Tribio InVivoMAb Anti-Mouse PD-L1 & CD28 Bispecific Antibody
TBS10183-1mgMonoclonal Anti-Thyroid Stimulating Hormone (TSH) Antibody
TBS10340-0.5MGInVivo Mouse IgG1 Isotype Control Antibody
121-220Exfection Plasmid EF (Exdotoxin Free, Midi)
TBS10482-100Tribio InVivoMAb Anti-Mouse PD-L1 & OX40 Bispecific Antibody

Popular Products