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Naratriptan HCl

CAT: 1568-C16348-02Size: 10 mM / 1 mLDry Ice: YesHazardous: No
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CAT#:1568-C16348-02Size:10 mM / 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
143388-64-1
SKU
C16348-10mg
Target
5-HT Receptor
Applications
Neuronal Signaling
Smiles
CNS (=O) (=O) CCC1=CC2=C (C=C1) NC=C2C3CCN (CC3) C.Cl
Molecular Formula
C17H25N3O2S.HCl
Additionnal Information
Naratriptan HCl is a triptan agent that is used for the treatment of migraine headaches.
Storage Conditions
2 years -80 in solvent

Chemical Information

Naratriptan Hydrochloride

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.

CAS Number143388-64-1
PubChem CID60875
IUPAC NameN-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide;hydrochloride
Molecular FormulaC17H26ClN3O2S
Molecular Weight371.9
Topological Polar Surface Area73.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity483
SMILES
CNS(=O)(=O)CCC1=CC2=C(C=C1)NC=C2C3CCN(CC3)C.Cl
InChI
InChI=1S/C17H25N3O2S.ClH/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14;/h3-4,11-12,14,18-19H,5-10H2,1-2H3;1H
InChIKey
AWEZYKMQFAUBTD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Naratriptan Hydrochloride
CAS: 143388-64-1
CID: 60875
Formula: C17H26ClN3O2S
MW: 371.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight371.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass371.1434259
Monoisotopic Mass371.1434259
Topological Polar Surface Area73.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity483
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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