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BX-795

CAT: 1568-C16223-01Size: 25 mgDry Ice: YesHazardous: No
CAT#:1568-C16223-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
702675-74-9
SKU
C16223-25mg
Target
IκB/IKK
Applications
NF-κB
Smiles
C1CCN (C1) C (=O) NC2=CC=CC (=C2) NC3=NC=C (C (=N3) NCCCNC (=O) C4=CC=CS4) I
Molecular Formula
C23H26IN7O2S
Additionnal Information
BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.
Storage Conditions
2 years -80 in solvent

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