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ENMD-2076

CAT: 1568-C16167-01Size: 10 mgDry Ice: YesHazardous: No
CAT#:1568-C16167-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
934353-76-1
SKU
C16167-10mg
Target
Aurora Kinase
Applications
Cell Cycle
Smiles
CC1=CC (=NN1) NC2=CC (=NC (=N2) C=CC3=CC=CC=C3) N4CCN (CC4) C
Molecular Formula
C21H25N7
Additionnal Information
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.
Storage Conditions
2 years -80 in solvent

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