Vandetanib

• CAS Number :

  443913-73-3

• Synonyms :

  ZD6474

• SKU :

  C16077-50mg

• Target :

  VEGFR

• Applications :

  Protein Tyrosine Kinase

• Smiles :

  CN1CCC (CC1) COC2=C (C=C3C (=C2) N=CN=C3NC4=C (C=C (C=C4) Br) F) OC

• Molecular Formula :

  C22H24BrFN4O2

• Additionnal Information :

  Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS) .

• Storage Conditions :

  2 years -80 in solvent