2BAct

CAT: 1568-C15165-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:1568-C15165-01Size:5 mg

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CAS Number

2143542-28-1

SKU

C15165-5mg

Smiles

O=C (C (C=N1) =NC=C1C (F) F) NC (C2) (C3) CC23NC (COC (C=C4) =CC (F) =C4Cl) =O

Molecular Formula

C19H16ClF3N4O3

Additionnal Information

2BAct is a potent, orally bioavailable eIF2B activator exhibiting high selectivity (EC50 = 33 nM) . It mitigates neurological impairments induced by persistent integrated stress response. The compound demonstrates blood-brain barrier penetration with enhanced solubility and pharmacokinetic properties compared to ISRIB trans-isomer .

Chemical Information

N-(3-(2-(4-Chloro-3-fluorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-5-(difluoromethyl)pyrazine-2-carboxamide

CAS Number	2143542-28-1
PubChem CID	132091799
IUPAC Name	N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]-1-bicyclo[1.1.1]pentanyl]-5-(difluoromethyl)pyrazine-2-carboxamide
Molecular Formula	C19H16ClF3N4O3
Molecular Weight	440.8
XLogP	2.2
Topological Polar Surface Area	93.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Heavy Atom Count	30
Formal Charge	0
Complexity	666

SMILES

C1C2(CC1(C2)NC(=O)C3=NC=C(N=C3)C(F)F)NC(=O)COC4=CC(=C(C=C4)Cl)F

InChI

InChI=1S/C19H16ClF3N4O3/c20-11-2-1-10(3-12(11)21)30-6-15(28)26-18-7-19(8-18,9-18)27-17(29)14-5-24-13(4-25-14)16(22)23/h1-5,16H,6-9H2,(H,26,28)(H,27,29)

InChIKey

HYQJXXCYOYRNMP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2143542-28-1

CID: 132091799

Formula: C19H16ClF3N4O3

MW: 440.8

Interactive 3D Structure

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Computed Properties

Property	Value
Molecular Weight	440.8
XLogP3	2.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Exact Mass	440.0863026
Monoisotopic Mass	440.0863026
Topological Polar Surface Area	93.2 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	666
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
GTR19165762-01	2BAct

2BAct

Chemical Information

Alternative Products

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