RG6344

CAT: 1568-C15138-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:1568-C15138-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2649372-20-1

Synonyms

B-Raf IN 2

SKU

C15138-5mg

Molecular Formula

C20H17F2N5O4S

Additionnal Information

RG6344 (RO7276389) is a brain penetrant inhibitor of BRAF which is designed to overcome the MAPK paradoxical activity. RG6344 can be used for the study of BRAF V600-mutant solid tumors, such as colorectal cancer (CRC) .

Chemical Information

(3R)-N-(2-cyano-4-fluoro-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)oxy)phenyl)-3-fluoropyrrolidine-1-sulfonamide

Mosperafenib is a small molecule drug. The usage of the INN stem '-rafenib' in the name indicates that Mosperafenib is a Raf (rapidly accelerated fibrosarcoma) kinase inhibitor. Mosperafenib has a monoisotopic molecular weight of 461.1 Da.

CAS Number	2649372-20-1
PubChem CID	156473463
IUPAC Name	(3R)-N-[2-cyano-4-fluoro-3-(3-methyl-4-oxoquinazolin-6-yl)oxyphenyl]-3-fluoropyrrolidine-1-sulfonamide
Molecular Formula	C20H17F2N5O4S
Molecular Weight	461.4
XLogP	2.2
Topological Polar Surface Area	123
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Heavy Atom Count	32
Formal Charge	0
Complexity	903

SMILES

CN1C=NC2=C(C1=O)C=C(C=C2)OC3=C(C=CC(=C3C#N)NS(=O)(=O)N4CC[C@H](C4)F)F

InChI

InChI=1S/C20H17F2N5O4S/c1-26-11-24-17-4-2-13(8-14(17)20(26)28)31-19-15(9-23)18(5-3-16(19)22)25-32(29,30)27-7-6-12(21)10-27/h2-5,8,11-12,25H,6-7,10H2,1H3/t12-/m1/s1

InChIKey

ZUXPFTYMSHPRQX-GFCCVEGCSA-N

Chemical Structure

2D Structure

CAS: 2649372-20-1

CID: 156473463

Formula: C20H17F2N5O4S

MW: 461.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	461.4
XLogP3	2.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Exact Mass	461.09693154
Monoisotopic Mass	461.09693154
Topological Polar Surface Area	123 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	903
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
E6419-5mg	RG6344

RG6344

Chemical Information

Alternative Products

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