Ensifentrine

• CAS Number :

  1884461-72-6

• Synonyms :

  RPL-554

• SKU :

  C14704-5mg

• Target :

  PDE

• Applications :

  Metabolism

• Molecular Formula :

  C26H31N5O4

• Additionnal Information :

  Ensifentrine (RPL-554) is a first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50 values of 0.4 nM and 1479 nM, respectively. Ensifentrine also inhibits lipopolysaccharide-induced tumor necrosis factor alpha release from human monocytes in a concentration-dependent manner. Ensifentrine demonstrates bronchoprotective and anti-inflammatory activities and can be used for chronic obstructive pulmonary disease (COPD) research.