Fluzoparib (SHR-3162)

CAT: 1568-C14432-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:1568-C14432-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1358715-18-0

Synonyms

HS10160

SKU

C14432-5mg

Target

PARP

Applications

DNA Damage/DNA Repair

Smiles

FC1=CC=C (CC2=NNC (=O) C3=C2C=CC=C3) C=C1C (=O) N4CC[N]5N=C (N=C5C4) C (F) (F) F

Molecular Formula

C22H16F4N6O2

Additionnal Information

Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity, with an IC50 of 1.46±0.72 nM for PARP1.

Storage Conditions

3 years -20°C powder

Chemical Information

Fuzuloparib

Fluzoparib is under investigation in clinical trial NCT03863860 (A Trial of Maintenance Treatment With Fluzoparib Versus Placebo in Relapsed Ovarian Cancer Patients).

CAS Number	1358715-18-0
PubChem CID	56649297
IUPAC Name	4-[[4-fluoro-3-[2-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl]phenyl]methyl]-2H-phthalazin-1-one
Molecular Formula	C22H16F4N6O2
Molecular Weight	472.4
XLogP	2.4
Topological Polar Surface Area	92.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Heavy Atom Count	34
Formal Charge	0
Complexity	839

SMILES

C1CN2C(=NC(=N2)C(F)(F)F)CN1C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

InChI

InChI=1S/C22H16F4N6O2/c23-16-6-5-12(10-17-13-3-1-2-4-14(13)19(33)29-28-17)9-15(16)20(34)31-7-8-32-18(11-31)27-21(30-32)22(24,25)26/h1-6,9H,7-8,10-11H2,(H,29,33)

InChIKey

XJGXCBHXFWBOTN-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1358715-18-0

CID: 56649297

Formula: C22H16F4N6O2

MW: 472.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	472.4
XLogP3	2.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	472.12708642
Monoisotopic Mass	472.12708642
Topological Polar Surface Area	92.5 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	839
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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S9712-25mg	Fluzoparib (SHR-3162)
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BA6159-1	SHR-1701
T9901A-1741-01	SHR-1703
GTR19196502	SHR-110008
GTR19144436-01	SHR-2042
HY-164763-01	SHR-A1201
PHY3866S	SHR Antibody
FS182635-01	SHR 0302

Fluzoparib (SHR-3162)

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