SRX3207

CAT: 1568-C13808-02Size: 25 mgDry Ice: NoHazardous: No

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CAT#:1568-C13808-02Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2254693-15-5

SKU

C13808-5mg

Target

Syk

Applications

Protein Tyrosine Kinase

Smiles

CC1=NN (C=C1CN2CCC2) C3=NC (=NC=C3) NC4=CC=C (C=C4) C5=CSC6=C5OC (=CC6=O) N7CCOCC7

Molecular Formula

C29H29N7O3S

Additionnal Information

SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.

Storage Conditions

3 years -20°C powder

Chemical Information

3-(4-((4-(4-(Azetidin-1-ylmethyl)-3-methyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)phenyl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one

CAS Number	2254693-15-5
PubChem CID	137357450
IUPAC Name	3-[4-[[4-[4-(azetidin-1-ylmethyl)-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]phenyl]-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
Molecular Formula	C29H29N7O3S
Molecular Weight	555.7
XLogP	4
Topological Polar Surface Area	126
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Heavy Atom Count	40
Formal Charge	0
Complexity	923

SMILES

CC1=NN(C=C1CN2CCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7

InChI

InChI=1S/C29H29N7O3S/c1-19-21(16-34-9-2-10-34)17-36(33-19)25-7-8-30-29(32-25)31-22-5-3-20(4-6-22)23-18-40-28-24(37)15-26(39-27(23)28)35-11-13-38-14-12-35/h3-8,15,17-18H,2,9-14,16H2,1H3,(H,30,31,32)

InChIKey

ZZVOPDBZUNUMPR-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2254693-15-5

CID: 137357450

Formula: C29H29N7O3S

MW: 555.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	555.7
XLogP3	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	555.20525899
Monoisotopic Mass	555.20525899
Topological Polar Surface Area	126 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	923
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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C03292-01	SRX3177
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C03292-100mg	SRX3177
C03292-25mg	SRX3177
C03292-5mg	SRX3177

Alternative Products

Catalog	Name
BA8751-10	SRX3207
A22305-50	SRX3207 50mg
A22305-5	SRX3207 5mg
A22305-25	SRX3207 25mg
A22305-10	SRX3207 10mg
A22305-1	SRX3207 1mg
A22305-200	SRX3207 200mg
A22305-100	SRX3207 100mg

SRX3207

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