SR-4835

CAT: 1568-C13758-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:1568-C13758-01Size:5 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2387704-62-1
SKU
C13758-5mg
Target
CDK
Applications
Cell Cycle
Smiles
CN1C=C (C=N1) N2C=NC3=C (N=C (N=C32) N4CCOCC4) NCC5=NC6=CC (=C (C=C6N5) Cl) Cl
Molecular Formula
C21H20Cl2N10O
Additionnal Information
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
Storage Conditions
3 years -20°C powder

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