GNE-781

• CAS Number :

  1936422-33-1

• SKU :

  C13573-5mg

• Target :

  Epigenetic Reader Domain

• Applications :

  Epigenetics

• Smiles :

  CNC (=O) N1CCC2=C (C1) C (=N[N]2C3CCOCC3) N4CCCC5=C4C=C (C (F) F) C (=C5) C6=C[N] (C) N=C6

• Molecular Formula :

  C27H33F2N7O2

• Additionnal Information :

  GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4 (1) with IC50 of 6.2 nM and 5100 nM, respectively. GNE-781 exhibits antitumor activity.

• Storage Conditions :

  3 years -20°C powder