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CBL0137 HCl

CAT: 1568-C13442-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:1568-C13442-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1197397-89-9
Synonyms
CBLC137 HCl, Curaxin 137 HCl
SKU
C13442-5mg
Target
P53
Applications
Apoptosis
Smiles
CC (C) NCCN1C2=C (C=C (C=C2) C (=O) C) C3=C1C=CC (=C3) C (=O) C.Cl
Molecular Formula
C21H24N2O2.HCl
Additionnal Information
CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-κB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex) .
Storage Conditions
2 years -80 in solvent

Chemical Information

Cblc137

a FACT histone chaperone inhibitor with antineoplastic activity; structure in first source

CAS Number1197397-89-9
PubChem CID44519123
IUPAC Name1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone;hydrochloride
Molecular FormulaC21H25ClN2O2
Molecular Weight372.9
Topological Polar Surface Area51.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity466
SMILES
CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl
InChI
InChI=1S/C21H24N2O2.ClH/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23;/h5-8,11-13,22H,9-10H2,1-4H3;1H
InChIKey
IXRKBBVMDMKAEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cblc137
CAS: 1197397-89-9
CID: 44519123
Formula: C21H25ClN2O2
MW: 372.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass372.1604557
Monoisotopic Mass372.1604557
Topological Polar Surface Area51.1 Ų
Heavy Atom Count26
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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