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SB239063

CAT: 1568-C12911-02Size: 10 mM / 1 mLDry Ice: YesHazardous: No
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CAT#:1568-C12911-02Size:10 mM / 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
193551-21-2
SKU
C12911-5mg
Target
P38 MAPK
Applications
MAPK
Smiles
COC1=NC=CC (=N1) C2=C (N=CN2C3CCC (CC3) O) C4=CC=C (C=C4) F
Molecular Formula
C20H21FN4O2
Additionnal Information
SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
Storage Conditions
2 years -80 in solvent

Chemical Information

SB 239063

SB-239063 is a member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of cyclohexanols, a member of imidazoles, an aromatic ether, a secondary alcohol, a member of pyrimidines and a member of monofluorobenzenes.

CAS Number193551-21-2
PubChem CID5166
IUPAC Name4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazol-1-yl]cyclohexan-1-ol
Molecular FormulaC20H21FN4O2
Molecular Weight368.4
XLogP2.6
Topological Polar Surface Area73.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity469
SMILES
COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F
InChI
InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3
InChIKey
ZQUSFAUAYSEREK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SB 239063
CAS: 193551-21-2
CID: 5166
Formula: C20H21FN4O2
MW: 368.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.4
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass368.16485409
Monoisotopic Mass368.16485409
Topological Polar Surface Area73.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity469
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1699-5SB239063
SD5937-25mgSB239063 (p38 MAPK inhibitor)

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