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LDC1267

CAT: 1568-C12834-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:1568-C12834-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1361030-48-9
SKU
C12834-5mg
Target
Tyro3
Applications
Protein Tyrosine Kinase
Smiles
CCOC1=CN (N=C1C (=O) NC2=CC (=C (C=C2) OC3=C4C=C (C (=CC4=NC=C3) OC) OC) F) C5=C (C=C (C=C5) F) C
Molecular Formula
C30H26F2N4O5
Additionnal Information
LDC1267 is a highly selective TAM kinase inhibitor with IC50 of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Displays lower activity against Met, Aurora B, Lck, Src, and CDK8.
Storage Conditions
2 years -80 in solvent

Chemical Information

Ldc1267
CAS Number1361030-48-9
PubChem CID56847486
IUPAC NameN-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide
Molecular FormulaC30H26F2N4O5
Molecular Weight560.5
XLogP5.7
Topological Polar Surface Area96.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Heavy Atom Count41
Formal Charge0
Complexity860
SMILES
CCOC1=CN(N=C1C(=O)NC2=CC(=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)F)C5=C(C=C(C=C5)F)C
InChI
InChI=1S/C30H26F2N4O5/c1-5-40-28-16-36(23-8-6-18(31)12-17(23)2)35-29(28)30(37)34-19-7-9-25(21(32)13-19)41-24-10-11-33-22-15-27(39-4)26(38-3)14-20(22)24/h6-16H,5H2,1-4H3,(H,34,37)
InChIKey
ISPBCAXOSOLFME-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ldc1267
CAS: 1361030-48-9
CID: 56847486
Formula: C30H26F2N4O5
MW: 560.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight560.5
XLogP35.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass560.18712627
Monoisotopic Mass560.18712627
Topological Polar Surface Area96.7 Ų
Heavy Atom Count41
Formal Charge0
Complexity860
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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